iPSC-Derived Therapies Bootcamp Day
Pre-Conference iPSC-Derived Therapies Bootcamp
Monday - May 17, 2021 | 10.30 - 2.30 EST 7.30 - 11.30 PST - All times shown in EDT
Join this bootcamp to be brought up to speed on the future of cell therapy!
Learn from the pioneers showcasing their next generation approach of utilizing iPSCs as a starting material for allogeneic therapy, outlining basic biology, differentiation, cell source material, safety risks and regulatory expectations.
The iPSC-Derived Therapies Bootcamp is Sponsored By: Solentim
Exclusive Expertise Partner
Solentim is the trusted global leader in workflows for antibody and cell based therapies. Our assurance rich technologies enable the isolation, growth and characterization of high value cells while our data driven platform enables smarter decision earlier in the process. Together, our customers experience faster workflows, confidently designed for regulatory environments.
10:30 am Online Registration & Virtual Coffee Networking
11:00 am iPSC Development, Biology and Therapies
Synopsis
• Brief overview/review of the history of iPSC development
• Biological characteristics that make iPSCs uniquely suited for cell-based therapies
• Optimal criteria for iPSCs to be used for therapies
11:30 am Effective iPSC Differentiation for Generation of CAR T Cells with Canonical T Cell Phenotype and CAR T Function
Synopsis
• Organoid culture supports the directional differentiation of CAR+ iPSCs into highly functional CAR T cells
• iPSC CAR T cells demonstrated endogenous T cell phenotypes and conventional CAR T cell functionality
• iPSC CAR T cells has unique characteristics favorable for the potent anti-tumor effect
12:00 pm Sourcing iPSC Lines for Clinical Use
Synopsis
• Donor material: what characteristics are critical to enable clinical use?
• Cell source: which cell type is best for reprogramming to generate your product?
• Cost and feasibility of generating a universal iPSC line for multiple products
12:30 pm Robust Workflow for Single Cell Cloning of iPSCs for Making cGMP Master Cell Banks
Synopsis
• Discuss the importance of the matrix, MatriClone™
• Illustrate the timeline improvements using the VIPS™ for single cell cloning iPSCs
• Discuss cGMP requirements and considerations in choice of platform
• Presentation of new data for gene-edited iPSC
1:00 pm Networking & Refreshment Break
Synopsis
Take this opportunity to stretch your legs, grab a coffee, and come back to join the online networking rooms where you can meet delegates of the bootcamp and discuss your learnings so far from the morning.
2:00 pm Trust Building – Approaches Toward Ensuring Product Safety With iPSC Based Cell Therapies
Synopsis
• Discuss approaches to ensure against residual iPSC in final products
• Preventing editing mischief during development of iPSC derived cell therapies
• Other approaches for safety including off switches and logic gating for activation
2:30 pm Regulatory Strategies for Accelerating Development of Cellular Therapies
Synopsis
• Setting regulatory expectations across cellular therapy landscape
• Demonstration of safety and efficacy – synergies between Chemistry, Manufacturing, and Control and Pharmacology/ Toxicology Investigations
• Effective communication and strategic alignment