ADAPT-NK – An Off-the-Shelf Allogeneic NK Cell Therapy Using Select Superdonors
Time: 2:00 pm
day: Day 1: Supply/Storage - Afternoon
Details:
- Using cryopreserved donor material from preselected ‘superdonors’ we developed a novel GMPcompliant NK cell expansion protocol – ADAPT-NK
- Superdonors were identified through selection criteria based on NK cell phenotype, as harboring large adaptive NK cell subsets with single self-KIR expression
- Expanded ADAPT-NK cells show strong alloreactivity in a mouse model of AML as well as against primary AML blasts ex vivo
